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In the current study, we claimed the identification and the characterization of a brand new atypical opioid receptor with unique detrimental regulatory Houses toward opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a wide-spectrum scavenger for opioid pept